Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.

Diabetologia - 1 Nov 1997

Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M

Abstract excerpt

Impaired glycogen synthesis after insulin stimulation accounts for most of the insulin resistance in patients with non-insulin-dependent diabetes mellitus (NIDDM). The glycogen synthase gene (GYS1), which encodes the rate-limiting enzyme for glycogen synthesis, is a promising candidate gene for NIDDM. Therefore, we screened all 16 exons of this gene by single-strand conformation polymorphism analysis in 40...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Finland
Share to Aged
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Glucose Tolerance Test

Share to Insulin Resistance

Share to Polymorphism, Genetic

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 9389424
DOI: 10.1007/s001250050826

Genes

GYS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.PMID 9389424Read ↗

A missense mutation of the muscle glycogen synthase gene (M416V) is associated with insulin resistance in the Japanese population.Semantic proximity Read ↗

Association of the glycogen synthase locus on 19q13 with NIDDM in Pima Indians.Semantic proximity Read ↗

Amino acid substitutions in hexokinase II among patients with NIDDM.Semantic proximity Read ↗

A new rare mutation (691delCC/insAAA) in exon 17 of the PYGM gene causing McArdle disease.Semantic proximity Read ↗

Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.Semantic proximity Read ↗

Polymorphism of the GLIS3 gene in a Caucasian population and among individuals with carbohydrate metabolism disorders in Russia.Semantic proximity Read ↗

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.Semantic proximity Read ↗

Sequence variations of the glucokinase gene in Japanese subjects with NIDDM.Semantic proximity Read ↗

A novel mutation in the glycogen synthase 2 gene in a child with glycogen storage disease type 0.Semantic proximity Read ↗

Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus in the Russian population.Semantic proximity Read ↗

Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.Semantic proximity Read ↗

Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.