Article
Glucokinase gene variants in the common form of NIDDM.
Diabetes - 1 Apr 1993
Chiu K C, Tanizawa Y, Permutt M A
Abstract excerpt
To determine whether a structural defect in glucokinase could be a primary cause of glucose intolerance in the common form of NIDDM, the prevalence of mutations in the gene in 60 American black NIDDM patients was investigated. First, by Southern blot analysis of DNA from a subset of randomly sele...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Diabetes Mellitus, Type 2
- Exons
- Gene Frequency
- Genetic Linkage
- Genetic Variation
- Glucokinase
- Humans
- Introns
- Islets of Langerhans
- Liver
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Repetitive Sequences, Nucleic Acid