Article
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 1996
Keohavong P, DeMichele M A, Melacrinos A C, Landreneau R J, Weyant R J, Siegfried J M
Abstract excerpt
The K-ras mutation is one of the most common genetic alterations found in human lung cancer. To evaluate the prognostic value of ras gene alterations in lung cancer in a U.S. population, we have screened 173 human lung tumors, which included 127 adenocarcinomas, 37 squamous carcinomas, and 9 adenosquamous carcinomas, for mutations in the K-ras gene using the combination of the PCR and denaturing gradient gel...
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