Article
The ras oncogenes in human lung cancer.
The American review of respiratory disease - 1 Dec 1990
Rodenhuis S, Slebos R J
Abstract excerpt
The three well-characterized genes of the ras gene family H-ras, K-ras, and N-ras, code for closely related 21-kD proteins that have a role in the transduction of growth signals. The ras proteins acquire transforming potential when a point mutation in the gene leads to replacement of an amino acid in one of the critical positions 12, 13, or 61. Overexpression of the normal protein, usually associated with gene...
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