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Article

Rational design of hirulog-type inhibitors of thrombin.

Journal of computer-aided molecular design - 1 Oct 1994

Egner U, Hoyer G A, Schleuning W D

Abstract excerpt

The two crystal structures of thrombin complexed with its most potent natural inhibitor hirudin and with the active-site inhibitor D-Phe-Pro-Arg-CH2Cl [Rydel, T.J. et al., J. Mol. Biol., 221 (1991) 583; Bode, W. et al., EMBO J., 8 (1989) 3467] were used as a basis to design a new inhibitor, combining the high specificity of the polypeptide hirudin with the simpler chemistry of an organic compound. In the new...

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PMID: 7876896
DOI: 10.1007/BF00123661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Rational design of hirulog-type inhibitors of thrombin.PMID 7876896Read ↗

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Use of fragments of hirudin to investigate thrombin-hirudin interaction.Semantic proximity Read ↗

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