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Article

NMR solution structure of a novel hirudin variant HM2, N-terminal 1-47 and N64-->V + G mutant.

Biopolymers - 1 Jun 1997

Nicastro G, Baumer L, Bolis G, Tatò M

Abstract excerpt

The 64 amino acid hirudin-like peptide HM2 (Hirudinaria manillensis) is one of the agents known to specifically block the blood-clotting enzyme thrombin, and therefore is used as a potential pharmacological tool for the treatment of arterial and venous thrombosis. This peptide and its derivatives provide a new set of probes for studies aimed at elucidating the structural basis of the inhibition of alpha-thrombin....

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Identifiers

PMID: 9128439
DOI: 10.1002/(SICI)1097-0282(199706)41:7<731::AID-BIP3>3.0.CO;2-Q

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