NMR solution structure of a novel hirudin variant HM2, N-terminal 1-47 and N64-->V + G mutant.

doi:10.1002/(SICI)1097-0282(199706)41:7<731::AID-BIP3>3.0.CO;2-Q

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Article

NMR solution structure of a novel hirudin variant HM2, N-terminal 1-47 and N64-->V + G mutant.

Biopolymers - 1 Jun 1997

Nicastro G, Baumer L, Bolis G, Tatò M

Abstract excerpt

The 64 amino acid hirudin-like peptide HM2 (Hirudinaria manillensis) is one of the agents known to specifically block the blood-clotting enzyme thrombin, and therefore is used as a potential pharmacological tool for the treatment of arterial and venous thrombosis. This peptide and its derivatives...

Topics

Amino Acid Sequence
Hirudins
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Mutation
Protein Conformation
Protein Structure, Secondary
Solutions

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