Hirudin: amino-terminal residues play a major role in the interaction with thrombin.

Article

Hirudin: amino-terminal residues play a major role in the interaction with thrombin.

The Journal of biological chemistry - 15 Jan 1991

Lazar J B, Winant R C, Johnson P H

Abstract excerpt

Amino acid substitutions within the amino-terminal 5 residues of the thrombin-specific inhibitor hirudin dramatically alter its ability to inhibit the thrombin-catalyzed hydrolysis of both a chromogenic substrate and fibrinogen. Replacing the highly conserved Tyr-3 residue with Trp or Phe increas...

Topics

Amino Acid Sequence
Hirudins
Models, Molecular
Molecular Sequence Data
Mutation
Protein Conformation
Thrombin

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