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Article

Hirudin binding reveals key determinants of thrombin allostery.

The Journal of biological chemistry - 22 Jul 2005

Mengwasser Kristen E, Bush Leslie A, Shih Peter, Cantwell Angelene M, Di Cera Enrico

Abstract excerpt

Thrombin exists in two allosteric forms, slow (S) and fast (F), that recognize natural substrates and inhibitors with significantly different affinities. Because under physiologic conditions the two forms are almost equally populated, investigation of thrombin function must address the contribution from the S and F forms and the molecular origin of their differential recognition of ligands. Using a panel of 79...

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PMID: 15923186
DOI: 10.1074/jbc.M502678200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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