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Article

Binding of hirudin to meizothrombin.

Protein engineering - 1 Aug 1998

Fischer B E, Schlokat U, Himmelspach M, Dorner F

Abstract excerpt

Prothrombin (coagulation factor II) is the inactive precursor molecule of thrombin (coagulation factor IIa). Proteolytic cleavage of the peptide bond Arg320-Ile321 converts prothrombin into the two-chain thrombin precursor meizothrombin. Meizothrombin hydrolyses peptidyl substrates, but cleavage of fibrinogen is poor. Unfortunately, meizothrombin exhibits a significant autocatalytic activity and thus is not...

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Identifiers

PMID: 9749925
DOI: 10.1093/protein/11.8.715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Binding of hirudin to meizothrombin.PMID 9749925Read ↗

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