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Article

Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.

Journal of medicinal chemistry - 9 Aug 2012

Abdel Aziz May H, Sidhu Preetpal Singh, Liang Aiye, Kim Ji Yeong, Mosier Philip D, Zhou Qibing, Farrell David H, Desai Umesh R

Abstract excerpt

Earlier, we reported on the design of sulfated benzofuran dimers (SBDs) as allosteric inhibitors of thrombin (Sidhu et al. J. Med. Chem.201154 5522-5531). To identify the site of binding of SBDs, we studied thrombin inhibition in the presence of exosite 1 and 2 ligands. Whereas hirudin peptide an...

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Identifiers

PMID: 22788964
DOI: 10.1021/jm300670q
PMCID: PMC3416887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22788964-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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