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Article

Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function.

Journal of virology - 1 Feb 1990

Cochrane A W, Perkins A, Rosen C A

Abstract excerpt

The human immunodeficiency virus rev gene product regulates the expression of viral structural genes. It was recently shown that Rev regulates the export of viral structural mRNAs from the nucleus to the cytoplasm. Analysis of Rev subcellular localization reveals marked accumulation in the nucleolus, suggesting a role for the nucleolus in this export process. We report here the identification of amino acid...

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Identifiers

PMID: 2404140
DOI: 10.1128/JVI.64.2.881-885.1990
PMCID: PMC249184

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