Article
Intracellular trafficking of the human immunodeficiency virus type 1 Rev protein: involvement of continued rRNA synthesis in nuclear retention.
AIDS research and human retroviruses - 1 Sept 1995
D'Agostino D M, Ciminale V, Pavlakis G N, Chieco-Bianchi L
Abstract excerpt
We have explored the mechanism directing the intracellular trafficking and nucleolar accumulation of the human immunodeficiency virus type 1 (HIV-1) Rev protein. Treatment of Rev-expressing cells with mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, resulted in a redistribu...
Topics
- Cell Nucleolus
- Cell Nucleus
- Dactinomycin
- Dichlororibofuranosylbenzimidazole
- Enzyme Inhibitors
- Gene Products, rev
- HIV-1
- HeLa Cells
- Humans
- IMP Dehydrogenase
- Mutation
- Mycophenolic Acid
- Protein Synthesis Inhibitors
- RNA, Ribosomal
- RNA, Viral
- rev Gene Products, Human Immunodeficiency Virus