Article
Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520.
Molecular and cellular biology - 1 Jan 1994
Raymond M, Ruetz S, Thomas D Y, Gros P
Abstract excerpt
We have recently reported that expression in yeast cells of P-glycoprotein (P-gp) encoded by the mouse multidrug resistance mdr3 gene (Mdr3) can complement a null ste6 mutation (M. Raymond, P. Gros, M. Whiteway, and D. Y. Thomas, Science 256:232-234, 1992). Here we show that Mdr3 behaves as a ful...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antifungal Agents
- Carrier Proteins
- Drug Resistance, Microbial
- Gene Expression
- Immunosuppressive Agents
- Membrane Glycoproteins
- Mice
- Mutation
- Saccharomyces cerevisiae
- Tacrolimus