Article
Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor.
Cancer research - 1 Mar 1995
Long L, Rubin R, Baserga R, Brodt P
Abstract excerpt
The ability of malignant cells to form metastases in secondary sites remains a major obstacle to the curative treatment of cancer. Previously, we identified type 1 insulin-like growth factor (IGF-1) as a paracrine mitogen for highly metastatic murine carcinoma, H-59 cells. Here the role of IGF-1 and its receptor (IGF-1R) in metastasis was further investigated using H-59 cells transfected with a plasmid vector...
Topics
- Animals
- Carcinoma, Lewis Lung
- Cell Division
- DNA, Complementary
- DNA, Neoplasm
- Injections, Subcutaneous
- Insulin-Like Growth Factor I
- Liver Neoplasms, Experimental
- Mice
- Neoplasm Transplantation
- Phenotype