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Article

Production of metastatic phenotype with DNA from metastatic cells but not with oncogenic DNA.

Cell biology international reports - 1 Aug 1990

Jamieson S, Barraclough R, Rudland P S

Abstract excerpt

Although the tumorigenic phenotype can be transferred by transfecting DNA from a variety of human tumours into 3T3 mouse fibroblasts, the ability to transfer the metastatic phenotype in a similar manner in syngeneic animals is largely unknown. We now report that transfection of a rat mammary epithelial cell line Rama 37, which produces nonmetastasizing adenomatous tumours in syngeneic rats, with DNA from a...

Topics

Animals
Antigens, Polyomavirus Transforming
DNA Restriction Enzymes
DNA, Neoplasm
DNA, Viral
Female
Genes, ras
Neoplasm Metastasis
Neoplasm Transplantation
Phenotype
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred WF

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 2171786
DOI: 10.1016/0309-1651(90)91190-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2171786-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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