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Article

The IGF-1 receptor and its contributions to metastatic tumor growth—novel approaches to the inhibition of IGF-1R function

1 Mar 2005

Abstract excerpt

Signals originating from the type 1 insulin-like growth factor receptor (IGF-1R) have pleiotropic effects on cell behavior. They regulate cell proliferation, survival, differentiation and transformation. IGF-1R also plays an essential role in the multistep process of cancer cell metastasis. Metastatic spread of tumor cells is the main reason for the high mortality rates associated with cancer. The development of...

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PMID: 16019422
DOI: 10.1080/08977190400020229

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