Article
Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior.
The American journal of psychiatry - 1 Mar 1995
Brett P M, Curtis D, Robertson M M, Gurling H M
Abstract excerpt
OBJECTIVE: Previous studies have demonstrated a relationship between obsessive-compulsive disorder or behavior and Gilles de la Tourette syndrome. It has been hypothesized that the serotonergic system is implicated in the etiology of obsessive-compulsive disorder. Therefore, the authors investiga...
Topics
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Variation
- Humans
- Lod Score
- Male
- Obsessive-Compulsive Disorder
- Pedigree
- Receptors, Serotonin
- Serotonin
- Tic Disorders
- Tourette Syndrome
- Tryptophan Oxygenase