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Article

COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study.

PloS one - 1 Jan 2015

Sampaio Aline Santos, Hounie Ana Gabriela, Petribú Kátia, Cappi Carolina, Morais Ivanil, Vallada Homero, do Rosário Maria Conceição, Stewart S Evelyn, Fargeness Jesen, Mathews Carol, Arnold Paul, Hanna Gregory L, Richter Margaret, Kennedy James, Fontenelle Leonardo, de Bragança Pereira Carlos Alberto, Pauls David L, Miguel Eurípedes Constantino

Abstract excerpt

OBJECTIVE: Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility. The catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAO-A) genes have been investigated in previous OCD studies, but the results are still unclear. More recently, Taylor...

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Identifiers

PMID: 25793616
DOI: 10.1371/journal.pone.0119592
PMCID: PMC4368617

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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