Article
Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder.
Biological psychiatry - 1 May 1999
Karayiorgou M, Sobin C, Blundell M L, Galke B L, Malinova L, Goldberg P, Ott J, Gogos J A
Abstract excerpt
BACKGROUND: Obsessive-compulsive disorder (OCD) is a common and severe psychiatric illness that affects 1-3% of the population and presents a well-established co-morbidity with major depressive disorder (MDD). Twin and family studies have suggested a genetic component in the etiology of OCD, although the mode of inheritance is unknown. Pharmacotherapy of the disease implicates both serotonergic and dopaminergic...
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