Article
Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder.
Biological psychiatry - 1 Feb 2007
Dickel Diane E, Veenstra-VanderWeele Jeremy, Bivens Nancy Chiu, Wu Xiaolin, Fischer Daniel J, Van Etten-Lee Michelle, Himle Joseph A, Leventhal Bennett L, Cook Edwin H, Hanna Gregory L
Abstract excerpt
BACKGROUND: Family-based evidence for association at serotonin system genes SLC6A4, HTR1B, HTR2A, and brain-derived neurotrophic factor (BDNF) has been previously reported in obsessive-compulsive disorder (OCD). Early-onset OCD is a more familial form of the disorder. METHODS: We used the transmission-disequilibrium test of association at common polymorphisms in each of these genes in 54 parent-child trios...
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