Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

Cell - 18 Sept 1992

Yin Y, Tainsky M A, Bischoff F Z, Strong L C, Wahl G M

Abstract excerpt

Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene amplification often occur during tumor progression, suggesting that they may be correlated. We show here that the wild-type p53 allele is lost when fibroblasts from patients with the Li-Fraumeni syndrome (LFS) are passaged in vitro. Normal and LFS cells containing wild-type p53 arrested in G1 when challenged with the uridine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Cycle
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Genes, p53

Share to Molecular Sequence Data

Share to Mutation

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 1525830
DOI: 10.1016/0092-8674(92)90244-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.PMID 1525830Read ↗

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.Semantic proximity Read ↗

Genomic instability and the role of p53 mutations in cancer cells.Semantic proximity Read ↗

Genetic instability as a consequence of inappropriate entry into and progression through S-phase.Semantic proximity Read ↗

Unaffected Li-Fraumeni Syndrome Carrier Parent Demonstrates Allele-Specific mRNA Stabilization of Wild-Type TP53 Compared to Affected Offspring.Semantic proximity Read ↗

Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families.Semantic proximity Read ↗

Induction of gene amplification as a gain-of-function phenotype of mutant p53 proteins.Semantic proximity Read ↗

Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA BreakageSemantic proximity Read ↗

Genomic stability and wild-type p53 function of lymphoblastoid cells with germ-line p53 mutation.Semantic proximity Read ↗

Cell cycle arrest defect in Li-Fraumeni Syndrome: a mechanism of cancer predisposition?Semantic proximity Read ↗

Relaxed cell-cycle arrests and propagation of unrepaired chromosomal damage in cancer cell lines with wild-type p53.Semantic proximity Read ↗

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control.Semantic proximity Read ↗

Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.