Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

doi:10.1016/0092-8674(92)90244-7

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Article

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

Cell - 18 Sept 1992

Yin Y, Tainsky M A, Bischoff F Z, Strong L C, Wahl G M

Abstract excerpt

Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene amplification often occur during tumor progression, suggesting that they may be correlated. We show here that the wild-type p53 allele is lost when fibroblasts from patients with the Li-Fraumeni syndrome (LFS) a...

Topics

Aspartic Acid
Base Sequence
Cell Cycle
Chromosome Deletion
Fibroblasts
G1 Phase
Gene Amplification
Genes, p53
Humans
Li-Fraumeni Syndrome
Molecular Sequence Data
Mutation
Phosphonoacetic Acid
S Phase
Suppression, Genetic
Tumor Cells, Cultured

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