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Article

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

Cell - 18 Sept 1992

Livingstone L R, White A, Sprouse J, Livanos E, Jacks T, Tlsty T D

Abstract excerpt

Gene amplification occurs at high frequency in transformed cells (10(-3)-10(-5)), but is undetectable in normal diploid fibroblasts (less than 10(-9)). This study examines whether alterations of one or both p53 alleles were sufficient to allow gene amplification to occur. Cells retaining one wild-type p53 allele mimicked the behavior of primary diploid cells: they arrested growth in the presence of drug and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1356076
DOI: 10.1016/0092-8674(92)90243-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.PMID 1356076Read ↗

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The properties of p53 proteins selected for the loss of suppression of transformation.Semantic proximity Read ↗

Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells.Semantic proximity Read ↗

A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotidesSemantic proximity Read ↗

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