Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

doi:10.1016/0092-8674(92)90243-6

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Article

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

Cell - 18 Sept 1992

Livingstone L R, White A, Sprouse J, Livanos E, Jacks T, Tlsty T D

Abstract excerpt

Gene amplification occurs at high frequency in transformed cells (10(-3)-10(-5)), but is undetectable in normal diploid fibroblasts (less than 10(-9)). This study examines whether alterations of one or both p53 alleles were sufficient to allow gene amplification to occur. Cells retaining one wild-type p53 allele mimicked the behavior of primary diploid cells: they arrested growth in the presence of drug and...

Topics

Animals
Aspartate Carbamoyltransferase
Aspartic Acid
Base Sequence
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
Cell Cycle
Cells, Cultured
Chromosome Deletion
Cytogenetics
Dihydroorotase
Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fibroblasts

Gene Amplification

Genes, p53

Germ Cells

Heterozygote

Humans

Li-Fraumeni Syndrome

Source

Open in PubMed

Identifiers

PMID: 1356076
DOI: 10.1016/0092-8674(92)90243-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1356076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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