Article
A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1.
Molecular and cellular biology - 1 Aug 1991
Kruger W, Herskowitz I
Abstract excerpt
The SIN1 gene was initially identified because mutations in SIN1 bypass the need for SWI1 to activate transcription of the yeast HO gene. We show here that transcription of HO in swi1 sin1 cells efficiently utilizes the normal start site. We have cloned SIN1 and found that it is identical to the previously identified gene SPT2, mutations in which allow transcription from certain mutated regulatory regions. The...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Nucleus
- Chromosomal Proteins, Non-Histone
- Chromosome Deletion
- Chromosomes, Fungal
- Cloning, Molecular
- Crosses, Genetic
- DNA-Binding Proteins
- Gene Expression Regulation, Fungal