Molecular and genetic analysis of the toxic effect of RAP1 overexpression in yeast.

doi:10.1093/genetics/141.4.1253

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Article

Molecular and genetic analysis of the toxic effect of RAP1 overexpression in yeast.

Genetics - 1 Dec 1995

Freeman K, Gwadz M, Shore D

Abstract excerpt

Rap1p is a context-dependent regulatory protein in yeast that functions as a transcriptional activator of many essential genes, including those encoding ribosomal proteins and glycolytic enzymes. Rap1p also participates in transcriptional silencing at HM mating-type loci and telomeres. Overexpression of RAP1 strongly inhibits cell growth, perhaps by interfering with essential transcriptional activation functions...

Topics

Alleles
Base Sequence
Basic-Leucine Zipper Transcription Factors
DNA, Fungal
DNA-Binding Proteins
Fungal Proteins
GTP-Binding Proteins
Genes, Lethal
Molecular Sequence Data
Point Mutation
Repressor Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
rap GTP-Binding Proteins

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Identifiers

PMID: 8601471
DOI: 10.1093/genetics/141.4.1253
PMCID: PMC1206864

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