HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene.

doi:10.1128/mcb.10.4.1439-1451.1990

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Article

HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene.

Molecular and cellular biology - 1 Apr 1990

Aguilera A, Klein H L

Abstract excerpt

The HPR1 gene has been cloned by complementation of the hyperrecombination phenotype of hpr1-1 strains by using a color assay system. HPR1 is a gene that is in single copy on chromosome IV of Saccharomyces cerevisiae, closely linked to ARO1, and it codes for a putative protein of 752 amino acids (molecular mass, 88 kilodaltons). Computer searches revealed homology (48.8% conserved homology; 24.8% identity) with...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Chromosomes, Fungal
Cloning, Molecular
DNA, Fungal
DNA, Ribosomal
Fungal Proteins
Genes, Fungal
Genetic Complementation Test
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nuclear Proteins

Plasmids

RNA, Fungal

Recombination, Genetic

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 2181275
DOI: 10.1128/mcb.10.4.1439-1451.1990
PMCID: PMC362246

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2181275-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene.PMID 2181275Read ↗

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