E-cadherin gene mutations in human gastric carcinoma cell lines.

doi:10.1073/pnas.91.5.1858

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

E-cadherin gene mutations in human gastric carcinoma cell lines.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1994

Oda T, Kanai Y, Oyama T, Yoshiura K, Shimoyama Y, Birchmeier W, Sugimura T, Hirohashi S

Abstract excerpt

Reduced expression of E-cadherin has been regarded as one of the main molecular events involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion and metastasis. However, even with a sufficient amount of E-cadherin, cell-cell adhesion is sometimes lost in "diffusely invasive" human carcinomas. Ten human cancer cell lines, showing growth characterized morphologically by loose cell-cell...

Topics

Amino Acid Sequence
Base Sequence
Cadherins
Cloning, Molecular
DNA Mutational Analysis
DNA Primers
DNA, Complementary
DNA, Neoplasm
Exons
Humans
Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

RNA, Messenger

RNA, Neoplasm

Stomach Neoplasms

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 8127895
DOI: 10.1073/pnas.91.5.1858
PMCID: PMC43263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8127895-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E-cadherin gene mutations in human gastric carcinoma cell lines.PMID 8127895Read ↗

Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines.Semantic proximity Read ↗

Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma.Semantic proximity Read ↗

Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.Semantic proximity Read ↗

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.Semantic proximity Read ↗

E-cadherin gene mutations are rare in adenocarcinomas of the oesophagus.Semantic proximity Read ↗

Identification of eleven novel tumor-associated E-cadherin mutations. Mutations in brief no. 215. Online.Semantic proximity Read ↗

Mutations of the human E-cadherin (CDH1) gene.Semantic proximity Read ↗

Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast.Semantic proximity Read ↗

A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination.Semantic proximity Read ↗

Frequent somatic allelic inactivation of the E-cadherin gene in gastric carcinomas.Semantic proximity Read ↗

Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.Semantic proximity Read ↗

Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.