Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells.

International journal of oncology - 1 Jul 2002

Vizirianakis Ioannis S, Chen Yao-Qi, Kantak Seema S, Tsiftsoglou Asterios S, Kramer Randall H

Abstract excerpt

Cadherins play a crucial role in epithelial morphogenesis and mediate intercellular adhesion. These receptors bind catenins and are involved in signal transduction pathways that regulate cell growth and apoptosis, and are frequently down-regulated in invasive and metastatic carcinomas. In order to assess the role of E-cadherin in cell adhesion and growth, we transfected MCF-7 cells, a human breast cancer cell...

Topics

Breast Neoplasms
Cadherins
Cell Adhesion
Cell Division
Cell Movement
Contact Inhibition
Cytoskeletal Proteins
Down-Regulation
Female
Genes, Dominant
H-2 Antigens
Humans
Mutation
Recombinant Fusion Proteins
Trans-Activators
Transfection
Tumor Cells, Cultured
Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 12063560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics