Article
Immortalization of carcinogen-treated Syrian hamster embryo cells occurs indirectly via an induced process.
Cancer research - 15 Apr 1992
Bols B L, Naaktgeboren J M, Lohman P H, Simons J W
Abstract excerpt
The hypothesis that rodent cells can be immortalized by the direct induction of a single mutation-like event was tested by initiating cultures of benzo(a)pyrene treated Syrian hamster embryo cells with low inocula and expanding these few cells maximally until senescence prevented further culturing or immortalization took place. According to the mutation hypothesis immortalization is hardly to be expected under...
Topics
- Animals
- Benzo(a)pyrene
- Cell Count
- Cell Transformation, Neoplastic
- Cricetinae
- Embryo, Mammalian
- Mesocricetus
- Mutation
- Probability