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Article

Altered p53 gene structure and expression in human epithelial cells after exposure to nickel.

Cancer research - 1 Jan 1992

Maehle L, Metcalf R A, Ryberg D, Bennett W P, Harris C C, Haugen A

Abstract excerpt

The carcinogenicity of certain nickel compounds is well known. We have previously shown that human kidney epithelial cells were immortalized by treatment with Ni(II) and in cooperation with the v-Ha-ras oncogene transformed the cells to acquire tumorigenicity in athymic nude mice. Immunocytochemistry and sequence analysis of DNA from the nickel-immortalized cells revealed abnormal p53 expression and a T----C...

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PMID: 1727381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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