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Article

A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease.

The New England journal of medicine - 16 Mar 1995

Lindpaintner K, Pfeffer M A, Kreutz R, Stampfer M J, Grodstein F, LaMotte F, Buring J, Hennekens C H

Abstract excerpt

BACKGROUND: In a previous study, men with a history of myocardial infarction were found to have an increased prevalence of homozygosity for the deletional allele (D) of the angiotensin-converting-enzyme (ACE) gene. The D allele is associated with higher levels of ACE, which may predispose a perso...

Topics

Alleles
Base Sequence
DNA Transposable Elements
Genotype
Humans
Logistic Models
Male
Middle Aged
Molecular Sequence Data
Myocardial Infarction
Myocardial Ischemia
Odds Ratio

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptidyl-Dipeptidase A

Polymerase Chain Reaction

Polymorphism, Genetic

Prospective Studies

Risk Factors

Source

Identifiers

PMID: 7854377
DOI: 10.1056/NEJM199503163321103

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7854377-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease.PMID 7854377Read ↗

Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke.Semantic proximity Read ↗

ACE gene polymorphism: ischemic heart disease and longevity in 10,150 individuals. A case-referent and retrospective cohort study based on the Copenhagen City Heart Study.Semantic proximity Read ↗

Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with increased plasma angiotensin-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease.Semantic proximity Read ↗

Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis.Semantic proximity Read ↗

Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of and prognosis after myocardial infarction.Semantic proximity Read ↗

Angiotensin-converting enzyme gene polymorphism is not associated with coronary atherosclerosis and myocardial infarction in a sample of Italian patients.Semantic proximity Read ↗

The angiotensin‐converting enzyme (ACE) genetic polymorphism: its relationship with plasma ACE level and myocardial infarctionSemantic proximity Read ↗

A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study.Semantic proximity Read ↗

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A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction.Semantic proximity Read ↗

Hypothesis: an angiotensin converting enzyme genotype, present in one in three caucasians, is associated with increased mortality rate.Semantic proximity Read ↗

Angiotensin I-converting enzyme insertion/deletion polymorphism: clinical implications.Semantic proximity Read ↗

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