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Article

A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease.

The New England journal of medicine - 16 Mar 1995

Lindpaintner K, Pfeffer M A, Kreutz R, Stampfer M J, Grodstein F, LaMotte F, Buring J, Hennekens C H

Abstract excerpt

BACKGROUND: In a previous study, men with a history of myocardial infarction were found to have an increased prevalence of homozygosity for the deletional allele (D) of the angiotensin-converting-enzyme (ACE) gene. The D allele is associated with higher levels of ACE, which may predispose a person to ischemic heart disease. We investigated the association between the ACE genotype and the incidence of myocardial...

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Identifiers

PMID: 7854377
DOI: 10.1056/NEJM199503163321103

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease.PMID 7854377Read ↗

Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke.Semantic proximity Read ↗

ACE gene polymorphism: ischemic heart disease and longevity in 10,150 individuals. A case-referent and retrospective cohort study based on the Copenhagen City Heart Study.Semantic proximity Read ↗

Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with increased plasma angiotensin-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease.Semantic proximity Read ↗

Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis.Semantic proximity Read ↗

Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of and prognosis after myocardial infarction.Semantic proximity Read ↗

Angiotensin-converting enzyme gene polymorphism is not associated with coronary atherosclerosis and myocardial infarction in a sample of Italian patients.Semantic proximity Read ↗

The angiotensin‐converting enzyme (ACE) genetic polymorphism: its relationship with plasma ACE level and myocardial infarctionSemantic proximity Read ↗

A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study.Semantic proximity Read ↗

Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators.Semantic proximity Read ↗

A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction.Semantic proximity Read ↗

Hypothesis: an angiotensin converting enzyme genotype, present in one in three caucasians, is associated with increased mortality rate.Semantic proximity Read ↗

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