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Article

A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction.

Circulation - 15 Aug 1996

Samani N J, Thompson J R, O'Toole L, Channer K, Woods K L

Abstract excerpt

BACKGROUND: The ACE gene is characterized by a polymorphism based on the presence (insertion [I]) or absence (deletion [D]) within intron 16 of a 287-basepair alu repeat sequence, resulting in three genotypes (DD and II homozygotes and ID heterozygotes). In 1992, the DD genotype was reported to be associated with an increased risk of myocardial infarction (MI). Subsequent studies have produced conflicting...

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Identifiers

PMID: 8772692
DOI: 10.1161/01.cir.94.4.708

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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