Article
Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with increased plasma angiotensin-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease.
Annals of internal medicine - 1 Jul 1996
Winkelmann B R, Nauck M, Klein B, Russ A P, Böhm B O, Siekmeier R, Ihnken K, Verho M, Gross W, März W
Abstract excerpt
BACKGROUND: Previous research has shown that the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene is a major determinant of plasma ACE activity. It has been suggested that persons with the DD genotype (those who express, on average, the highest levels of circulating ACE) have an increased risk for myocardial infarction and coronary artery disease, particularly if they are...
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