A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study.

doi:10.1161/01.cir.91.2.270

Back to search

Article

A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study.

Circulation - 15 Jan 1995

Mattu R K, Needham E W, Galton D J, Frangos E, Clark A J, Caulfield M

Abstract excerpt

BACKGROUND: We analyzed an insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene in 1226 subjects from the Caerphilly Prospective Heart Disease Study. Amplification of genomic DNA using the polymerase chain reaction yielded the genotypes II, ID, and DD. Distribut...

Topics

Alleles
Coronary Disease
DNA
Gene Amplification
Gene Frequency
Genetic Variation
Genotype
Humans
Middle Aged
Peptidyl-Dipeptidase A
Polymorphism, Genetic
Risk Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.