Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study.

Circulation - 15 Jan 1995

Mattu R K, Needham E W, Galton D J, Frangos E, Clark A J, Caulfield M

Abstract excerpt

BACKGROUND: We analyzed an insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene in 1226 subjects from the Caerphilly Prospective Heart Disease Study. Amplification of genomic DNA using the polymerase chain reaction yielded the genotypes II, ID, and DD. Distribution of the polymorphism was analyzed among the whole group and within subgroups (specified following multiple risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Variation

Share to Genotype

Share to Polymorphism, Genetic

Share to Risk Factors

Source

Identifiers

PMID: 7805228
DOI: 10.1161/01.cir.91.2.270

Genes

CAD
ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study.PMID 7805228Read ↗

Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with increased plasma angiotensin-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease.Semantic proximity Read ↗

Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphic Variant as a Marker of Coronary Artery Disease<subtitle>A Meta-analysis</subtitle>Semantic proximity Read ↗

Angiotensin-I converting enzyme genotype DD is a risk factor for coronary artery disease.Semantic proximity Read ↗

Angiotensin-I-converting enzyme DD genotype is a risk factor of coronary artery disease.Semantic proximity Read ↗

Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of and prognosis after myocardial infarction.Semantic proximity Read ↗

Angiotensin I-converting enzyme insertion/deletion polymorphism: clinical implications.Semantic proximity Read ↗

Angiotensin-converting enzyme genotypes and risk for myocardial infarction in women.Semantic proximity Read ↗

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction.Semantic proximity Read ↗

The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk.Semantic proximity Read ↗

Hypothesis: an angiotensin converting enzyme genotype, present in one in three caucasians, is associated with increased mortality rate.Semantic proximity Read ↗

The D allele of the angiotensin-converting enzyme gene contributes towards blood LDL-cholesterol levels and the presence of hypertension.Semantic proximity Read ↗

Traditional risk factors and angiotensin-converting enzyme insertion/deletion gene polymorphism in coronary artery disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.