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Article

Cloning and expression of a Xenopus gene that prevents mitotic catastrophe in fission yeast.

Molecular & general genetics : MGG - 6 Feb 1995

Su J Y, Maller J L

Abstract excerpt

In fission yeast the Wee1 kinase and the functionally redundant Mik1 kinase provide a regulatory mechanism to ensure that mitosis is initiated only after the completion of DNA synthesis. Yeast in which both Wee1 and Mik1 kinases are defective exhibit a mitotic catastrophe phenotype, presumably due to premature entry into mitosis. Because of the functional conservation of cell cycle control elements, the...

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PMID: 7854324
DOI: 10.1007/BF00288613

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