Cloning and expression of a Xenopus gene that prevents mitotic catastrophe in fission yeast.

doi:10.1007/BF00288613

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Article

Cloning and expression of a Xenopus gene that prevents mitotic catastrophe in fission yeast.

Molecular & general genetics : MGG - 6 Feb 1995

Su J Y, Maller J L

Abstract excerpt

In fission yeast the Wee1 kinase and the functionally redundant Mik1 kinase provide a regulatory mechanism to ensure that mitosis is initiated only after the completion of DNA synthesis. Yeast in which both Wee1 and Mik1 kinases are defective exhibit a mitotic catastrophe phenotype, presumably due to premature entry into mitosis. Because of the functional conservation of cell cycle control elements, the...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Cycle Proteins
Cloning, Molecular
DNA, Complementary
Gene Expression Regulation, Enzymologic
Genetic Complementation Test
Maturation-Promoting Factor
Mitosis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Phenotype

Phosphorylation

Protein-Tyrosine Kinases

RNA, Messenger

Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 7854324
DOI: 10.1007/BF00288613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7854324-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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