Article
Cold-sensitive mutants of p34cdc2 that suppress a mitotic catastrophe phenotype in fission yeast.
Molecular & general genetics : MGG - 1 Apr 1992
Ayscough K, Hayles J, MacNeill S A, Nurse P
Abstract excerpt
The p34cdc2 protein kinase plays a central role in the regulation of the eukaryotic cell cycle, being required both in late G1 for the commitment to S-phase and in late G2 for the initiation of mitosis. p34cdc2 also determines the precise timing of entry into mitosis in fission yeast, where a number of gene products that regulate p34cdc2 activity have been identified and characterised. To investigate further the...
Topics
- Alleles
- Amino Acid Sequence
- CDC2 Protein Kinase
- Cell Cycle
- Cloning, Molecular
- Cold Temperature
- Methylnitronitrosoguanidine
- Molecular Sequence Data
- Molecular Weight
- Mutagenesis
- Phenotype