Article
The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle.
The EMBO journal - 15 May 2002
Okamoto Kengo, Nakajo Nobushige, Sagata Noriyuki
Abstract excerpt
In eukaryotic cells, the Wee1 protein kinase phosphorylates and inhibits Cdc2, thereby creating an interphase of the cell cycle. In Xenopus, the conventional Wee1 homolog (termed Xe-Wee1A, or Wee1A for short) is maternally expressed and functions in pregastrula embryos with rapid cell cycles. Here, we have isolated a second, zygotic isoform of Xenopus Wee1, termed Xe-Wee1B (or Wee1B for short), that is expressed...
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