Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis.

doi:10.1093/genetics/155.1.159

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Article

Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis.

Genetics - 1 May 2000

Price D, Rabinovitch S, O'Farrell P H, Campbell S D

Abstract excerpt

In Drosophila, the maternally expressed mei-41 and grp genes are required for successful execution of the nuclear division cycles of early embryogenesis. In fission yeast, genes encoding similar kinases (rad3 and chk1, respectively) are components of a cell cycle checkpoint that delays mitosis by inhibitory phosphorylation of Cdk1. We have identified mutations in a gene encoding a Cdk1 inhibitory kinase,...

Topics

Alleles
Amino Acid Sequence
Animals
Cell Cycle Proteins
Cell Nucleus
Checkpoint Kinase 1
Drosophila
Drosophila Proteins
Female
Genes, Insect
Male
Molecular Sequence Data
Mutagenesis
Nuclear Proteins
Protein-Tyrosine Kinases
Schizosaccharomyces pombe Proteins

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Identifiers

PMID: 10790391
DOI: 10.1093/genetics/155.1.159
PMCID: PMC1461082

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