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Article

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

1 Jan 2015

Abstract excerpt

Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote the unrestrained growth of defective cells, thereby representing a major gateway to tumour...

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PMID: 26491220
DOI: 10.1155/2015/146282

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