Article
Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene.
The Journal of biological chemistry - 17 Feb 1995
Homanics G E, de Silva H V, Osada J, Zhang S H, Wong H, Borensztajn J, Maeda N
Abstract excerpt
In order to gain better understanding of the function of hepatic lipase (HL) in vivo, we have generated mice that lack HL using gene targeting in embryonic stem cells. No mRNA for HL was detected in the liver of homozygous mutants, and no HL activity was detected in their plasma. Total cholesterol levels in plasma of mutant mice were increased by about 30% compared with wild type animals. Plasma phospholipids and...
Topics
- Alleles
- Animals
- Apolipoproteins
- Blastocyst
- Blotting, Northern
- Chylomicrons
- Dietary Fats, Unsaturated
- Female
- Gene Expression
- Hyperlipidemias
- Lipase