Article
Mouse models of disturbed HDL metabolism.
Handbook of experimental pharmacology - 1 Jan 2015
Hoekstra Menno, Van Eck Miranda
Abstract excerpt
High-density lipoprotein (HDL) is considered to be an anti-atherogenic lipoprotein moiety. Generation of genetically modified (total body and tissue-specific knockout) mouse models has significantly contributed to our understanding of HDL function. Here we will review data from knockout mouse studies on the importance of HDL's major alipoprotein apoA-I, the ABC transporters A1 and G1, lecithin:cholesterol...
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