Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003

Ma Ke, Cilingiroglu Mehmet, Otvos James D, Ballantyne Christie M, Marian Ali J, Chan Lawrence

Abstract excerpt

High-density lipoprotein (HDL) protects against atherosclerosis. Endothelial lipase (EL) has been postulated to be involved in lipoprotein, and possibly HDL, metabolism, yet the evidence has been scarce and conflicting. We have inactivated EL in mice by gene targeting. EL(-/-) mice have elevated plasma and HDL cholesterol, and increased apolipoproteins A-I and E. NMR analysis reveals an abundance of large HDL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins
Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Lipase

Share to Lipoprotein Lipase

Share to Lipoproteins, HDL

Share to Phosphatidylcholines

Share to Phospholipids

Source

Open in PubMed Open full text

Identifiers

PMID: 12601178
DOI: 10.1073/pnas.0438039100
PMCID: PMC151412

Genes

LIPG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism.PMID 12601178Read ↗

Endothelial lipase is a major determinant of HDL level.Semantic proximity Read ↗

Endothelial lipase is a major determinant of HDL levelSemantic proximity Read ↗

Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice.Semantic proximity Read ↗

Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis.Semantic proximity Read ↗

Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol.Semantic proximity Read ↗

Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.Semantic proximity Read ↗

Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis.Semantic proximity Read ↗

A rare gain of function variant of hepatic lipase attenuates hypercholesterolaemia and atherosclerosis in mice via an LDL receptor-independent mechanism.Semantic proximity Read ↗

Endothelial Lipase Variant, T111I, Does Not Alter Inhibition by Angiopoietin-like ProteinsSemantic proximity Read ↗

Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits.Semantic proximity Read ↗

Genetic and structure-function studies of missense mutations in human endothelial lipase.Semantic proximity Read ↗

Lipoprotein lipase: genetics, lipid uptake, and regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.