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Article

Mouse hepatic lipase alleles with variable effects on lipoprotein composition and size.

Journal of lipid research - 1 May 2010

Pratt Serena M, Chiu Sally, Espinal Glenda M, Shibata Noreene M, Wong Howard, Warden Craig H

Abstract excerpt

The structural features responsible for the activities of hepatic lipase (HL) can be clarified by in vivo comparisons of naturally occurring variants. The coding sequence of HL from C57BL/6J (B6) and SPRET/EiJ (SPRET) mice differs by four amino acids (S106N, A156V, L416V, S480T); however, these changes are not predicted to influence HL function. To test for allelic effects, we generated SPRET-HL transgenics with...

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Identifiers

PMID: 19965617
DOI: 10.1194/jlr.M002378
PMCID: PMC2853430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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