Article
Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.
The Journal of clinical investigation - 1 Dec 1995
Weinstock P H, Bisgaier C L, Aalto-Setälä K, Radner H, Ramakrishnan R, Levak-Frank S, Essenburg A D, Zechner R, Breslow J L
Abstract excerpt
Lipoprotein lipase (LPL)-deficient mice have been created by gene targeting in embryonic stem cells. At birth, homozygous knockout pups have threefold higher triglycerides and sevenfold higher VLDL cholesterol levels than controls. When permitted to suckle, LPL-deficient mice become pale, then cyanotic, and finally die at approximately 18 h of age. Before death, triglyceride levels are severely elevated (15,087...
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