Article
Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice.
Journal of lipid research - 1 Jun 1998
Semenkovich C F, Coleman T, Daugherty A
Abstract excerpt
Heterozygous lipoprotein lipase deficiency (LPL+/-) is common and has been implicated in premature atherosclerosis in epidemiologic studies. However, in vitro data suggest that LPL deficiency in the vascular wall may be antiatherogenic. To address the role of LPL in atherosclerosis, LPL+/- mice i...
Topics
- Animals
- Aorta
- Arteriosclerosis
- Cholesterol
- Cholesterol, HDL
- Crosses, Genetic
- Diet, Atherogenic
- Female
- Genotype
- Heterozygote
- Homozygote
- Lipoprotein Lipase
- Macrophages
- Male
- Mice
- Mice, Knockout
- Receptors, LDL
- Sex Characteristics