Article
Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma.
The Journal of biological chemistry - 4 Jul 1997
Levak-Frank S, Weinstock P H, Hayek T, Verdery R, Hofmann W, Ramakrishnan R, Sattler W, Breslow J L, Zechner R
Abstract excerpt
To determine the contribution of muscle lipoprotein lipase (LPL) to lipoprotein metabolism, induced mutant mice were generated that express human LPL exclusively in muscle. By cross-breeding heterozygous LPL knockout mice with transgenic mice expressing human LPL only in muscle, animals were obta...
Topics
- Animals
- Cholesterol, HDL
- Energy Metabolism
- Female
- Genotype
- Heparin
- Humans
- Lipids
- Lipoprotein Lipase
- Lipoproteins
- Male
- Mice
- Mice, Knockout
- Mice, Transgenic
- Muscles
- Triglycerides