Article
Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma.
The Journal of biological chemistry - 4 Jul 1997
Levak-Frank S, Weinstock P H, Hayek T, Verdery R, Hofmann W, Ramakrishnan R, Sattler W, Breslow J L, Zechner R
Abstract excerpt
To determine the contribution of muscle lipoprotein lipase (LPL) to lipoprotein metabolism, induced mutant mice were generated that express human LPL exclusively in muscle. By cross-breeding heterozygous LPL knockout mice with transgenic mice expressing human LPL only in muscle, animals were obtained that express human LPL primarily in skeletal muscle on either the null (L0-MCK) or normal (L2-MCK) LPL...
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