Article
p53 protein overexpression and allele loss of p53 gene in gastric adenocarcinoma.
Journal of Korean medical science - 1 Aug 1994
Choi S W, Park W S, Yang J M, Kang C S, Sun H S, Kim B S, Seo E J, Lee M J, Park C S
Abstract excerpt
Gene alterations of p53 tumor suppressor gene such as point mutations, deletions or insertions occur in various human cancers. p53 protein overexpression was studied immunohistochemically in 80 gastric adenocarcinomas using an anti-human p53 antibody (Pab 1801) and the avidin-biotin-peroxidase technique. We have also analyzed allele loss of the human p53 gene in 54 cases of gastric adenocarcinoma using polymerase...
Topics
- Adenocarcinoma
- Alleles
- Base Sequence
- DNA, Neoplasm
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genetic Markers
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length