Article
Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas.
The Prostate - 1 Jan 1995
Brooks J D, Bova G S, Isaacs W B
Abstract excerpt
Inactivation of the retinoblastoma (Rb) gene has been implicated in the genesis and progression of a number of tumor types, including prostatic adenocarcinomas. We have analyzed a series of 46 surgically-resected human prostatic adenocarcinomas for allelic loss of the Rb gene with PCR amplification of a highly polymorphic region of the gene. 41 of 46 tumors (89%) were informative and 11 of these (27%) had lost...
Topics
- Adenocarcinoma
- Alleles
- Base Sequence
- Gene Deletion
- Genes, Retinoblastoma
- Humans
- Male
- Molecular Sequence Data
- Prostatic Neoplasms