Article
Biochemical and genetic analysis of the Chinese hamster mutants irs1 and irs2 and their comparison to cultured ataxia telangiectasia cells.
Mutagenesis - 1 Jan 1990
Jones N J, Stewart S A, Thompson L H
Abstract excerpt
Two mutants of the Chinese hamster cell line V79-4 (irs1 and irs2) were previously isolated on the basis of their hypersensitivity (2- to 3-fold) to cell inactivation by ionizing radiation. One of these mutants, irs1, displays an unusual phenotype of cross-sensitivity to other varied genotoxic ag...
Topics
- Animals
- Ataxia Telangiectasia
- Cell Line
- Cisplatin
- Cricetinae
- Cricetulus
- DNA
- DNA Repair
- Dose-Response Relationship, Radiation
- Gamma Rays
- Genetic Complementation Test
- Humans
- Hybrid Cells
- Lymphocytes
- Mesylates
- Mitomycin
- Mitomycins
- Mutation