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Biochemical and genetic analysis of the Chinese hamster mutants irs1 and irs2 and their comparison to cultured ataxia telangiectasia cells.

Mutagenesis - 1 Jan 1990

Jones N J, Stewart S A, Thompson L H

Abstract excerpt

Two mutants of the Chinese hamster cell line V79-4 (irs1 and irs2) were previously isolated on the basis of their hypersensitivity (2- to 3-fold) to cell inactivation by ionizing radiation. One of these mutants, irs1, displays an unusual phenotype of cross-sensitivity to other varied genotoxic agents including UV light (2- to 3-fold), ethyl methanesulphonate (approximately 10-fold) and mitomycin C (approximately...

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PMID: 2158612
DOI: 10.1093/mutage/5.1.15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Biochemical and genetic analysis of the Chinese hamster mutants irs1 and irs2 and their comparison to cultured ataxia telangiectasia cells.PMID 2158612Read ↗

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