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Slippage--misalignment: to what extent does it contribute to mammalian cell mutagenesis?

Mutagenesis - 1 Sept 1994

Kimura H, Iyehara-Ogawa H, Kato T

Abstract excerpt

Mutations in mammalian genomes are the result of several mutagenic processes that are intrinsic to cell metabolism. Analysis of the mutation spectrum of a chromosomal gene is a valuable tool for assessing the contribution of these mechanisms to mutagenesis in the cell. We have studied the specificity of mutations induced by various mutagens in a cDNA hprt gene integrated in a chromosome of a mouse cell line. To...

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PMID: 7837971
DOI: 10.1093/mutage/9.5.395

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