Slippage--misalignment: to what extent does it contribute to mammalian cell mutagenesis?

doi:10.1093/mutage/9.5.395

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Article

Slippage--misalignment: to what extent does it contribute to mammalian cell mutagenesis?

Mutagenesis - 1 Sept 1994

Kimura H, Iyehara-Ogawa H, Kato T

Abstract excerpt

Mutations in mammalian genomes are the result of several mutagenic processes that are intrinsic to cell metabolism. Analysis of the mutation spectrum of a chromosomal gene is a valuable tool for assessing the contribution of these mechanisms to mutagenesis in the cell. We have studied the specifi...

Topics

Animals
Cells, Cultured
DNA Damage
DNA, Complementary
Genes, APC
Genes, p53
Humans
Hypoxanthine Phosphoribosyltransferase
Mice
Models, Genetic
Mutagenesis
Mutation

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