Errors in DNA synthesis: a source of spontaneous mutations.

doi:10.1016/0165-1110(90)90021-3

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Article

Errors in DNA synthesis: a source of spontaneous mutations.

Mutation research - 1 May 1990

Loeb L A, Cheng K C

Abstract excerpt

Spontaneous mutations in somatic cells may engender several pathologic processes, including cancer. The sources of these mutations remain to be established. We present a conceptual framework in which to analyze the sources of spontaneous mutations and focus here on 3 endogenous processes that hav...

Topics

Animals
DNA Damage
DNA Replication
Deoxyribonucleotides
Free Radicals
Humans
Mutation
Oxygen
Purines

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