Article
Errors in DNA synthesis: a source of spontaneous mutations.
Mutation research - 1 May 1990
Loeb L A, Cheng K C
Abstract excerpt
Spontaneous mutations in somatic cells may engender several pathologic processes, including cancer. The sources of these mutations remain to be established. We present a conceptual framework in which to analyze the sources of spontaneous mutations and focus here on 3 endogenous processes that have the potential to generate spontaneous sequence alterations in DNA. These are: replication errors, depurination of...
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